This Reprint compiles original research and review articles examining the molecular genetic mechanisms and breeding innovations shaping modern ruminant livestock production. Bringing together studies on cattle, sheep, and goats, the collection spans a broad range of topics including genomic selection, genome-wide association studies, functional gene annotation, epigenetics, non-coding RNA, and multi-omics integration. Contributions draw on cutting-edge technologies such as next-generation sequencing, CRISPR-Cas genome editing, transcriptomics, proteomics, and metabolomics to advance the understanding of traits related to economic traits, disease resistance, and environmental adaptability. Studies address the identification of quantitative trait loci, single nucleotide polymorphisms, and candidate genes, as well as the optimization of genomic prediction models and selective breeding strategies for sustainable ruminant agriculture. The Reprint reflects a global research effort, featuring investigations into diverse breeds and populations across multiple agro-ecological contexts. Collectively, the articles presented in this Reprint provide a comprehensive and current foundation for precision breeding in cattle, sheep, and goats, with practical implications for improving productivity, genetic diversity management, and the long-term sustainability of ruminant production systems.
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