ANTI-INFLAMMATORY Comparison OF BETA-ESCIN AND ESCUZAN IN CrushSyndrom: COMPARATIVE ANALYSIS THE PROPERTIES EXPERIMENTAL CRUSH SYNDROME

This monograph presents a comparative analysis of the anti-inflammatory properties of the new drugs Beta-escin and Escuzan in an experimental model of Crush syndrome. It analyses the anti-inflammatory effect of the new drug Beta-escin in experimental Crush syndrome, its impact on interleukin-1ß, interleukin-6, tumour necrosis factor-¿, osteocalcin, alkaline and acid phosphatase, and on fibrinogen levels. The study also examines the effect of Beta-escin on elevated blood creatinine and urea levels in rats with experimental acute renal ischemia, as well as its impact on the lifespan of experimental animals in a model of global cerebral ischemia. Beta-escin displayed pronounced anti-inflammatory effects by reducing exudation and cellular proliferation, outperforming the reference drug Escuzan. This monograph is intended for medical professionals, researchers, and academic staff working in the field of medicine. It may also be useful for postgraduate students and doctoral candidates engaged in clinical and experimental studies. The content serves as a concise resource for both scientific research and practical medical applications.