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Aryl Hydrocarbon Receptor
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The Aryl hydrocarbon receptor is a member of the family of basic-helix-loop-helix transcription factors. AhR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT, leading to changes in gene transcription.
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The Aryl hydrocarbon receptor is a member of the family of basic-helix-loop-helix transcription factors. AhR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT, leading to changes in gene transcription.
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