Autoimmune Lymphoproliferative Syndrome

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Autoimmune lymphoproliferative syndrome is a form of lymphoproliferative disorder. It affects lymphocyte apoptosis. ALPS results from mutations in the human genes, Fas and FasL, which are upstream effectors of the apoptotic pathway in cells. Lymphoproliferative disorders (LPDs) refer to several conditions in which lymphocytes are produced in excessive quantities. They typically occur in patients who have compromised immune systems. They are sometimes equated with "immunoproliferative disorders", but technically Lymphoproliferative disorders are a subset of immunoproliferative disorders, along with hypergammaglobulinemia and paraproteinemias.