Biological Mechanisms in the Treatment of Neuropsychiatric Diseases

This Special Issue of Cells includes original research and state-of-the-art reviews across a number of neuropsychiatric conditions with a focus on cell and molecular biology, pathological disease mechanisms, and novel treatment approaches. It includes original nonclinical data on a novel ALDH2 inhibitor for alcohol use disorder, rodent and human data from studies of a novel GABA-A receptor positive allosteric modulator, and studies of an mGlu5 positive allosteric modulator and adenosine A(2A) agonist in a rodent model of psychosis. In addtion, there are also literature reviews on neurophysiological correlates of cognitive impairment in ALS, epigenetics and gut microbiota in bipolar disorder, autophagy in Alzheimer's disease, modulation of histone acetyltransferases as treatment for neurodegenerative diseases, neurobiological mechanisms of psychological dysfunction after brain injury, and mechanisms of non-invasive brain stimulation treatments.