Cancer Immunotherapy

This reprint provides an updated overview of the evolving role of radiotherapy within a personalized oncology framework, with particular attention to its integration with systemic treatments and its impact on tumor-immune interactions. The contributions included highlight the clinical and translational relevance of combining radiotherapy with immunotherapy as well as targeted agents across different tumor types, with a focus on treatment response, disease control, and safety profiles. In addition, several studies explore the modulation of the tumor microenvironment and immune response induced by radiation, as well as the potential role of predictive biomarkers in guiding therapeutic decisions. Overall, this collection reflects current efforts to optimize radiotherapy-based strategies through a more precise and biologically informed approach, highlighting their synergistic interplay with immunotherapy and their role in shaping anti-tumor immune responses, ultimately supporting the development of tailored treatment paradigms in modern oncology.