Cancer Signaling

This text focuses on the essentials in molecular oncology. In particular, signaling pathways that affect a different types of cancers are covered in detail. The textbook is written in an easily accessible style and includes 32 educational videos. Cancer, which has become the second-most prevalent health issue globally, is essentially resulting from a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow a cancer to thrive - and how these networks can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors tell a compelling story of how cancer works at the molecular level, and how targeted therapies - using kinase inhibitors and other modulators of signaling pathways - can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their functions in healthy versus cancer cells. Coloured figures and the text which is written in plain style make the complex topic easy to understand. Specially prepared teaching videos on key concepts and pathways in cancer signaling illustrate the most relevant aspects. They are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.