Cruciferous Glucosinolates in Metabolic Disease Management

Cruciferous vegetables have attracted considerable scientific interest because of their rich content of glucosinolates, a unique class of sulfur-containing phytochemicals associated with numerous health-promoting effects. Upon plant disruption, glucosinolates are hydrolyzed into biologically active metabolites, including isothiocyanates and indoles, which influence diverse cellular and molecular pathways. Growing evidence from experimental, epidemiological, and clinical studies suggests that these compounds contribute to disease prevention and health maintenance through antioxidant, anti-inflammatory, detoxification, and metabolic regulatory mechanisms. This book explores the chemistry, occurrence, bioavailability, metabolism, and biological activities of glucosinolates and their derivatives. It further examines the molecular mechanisms underlying their actions and evaluates their role in the modulation of chronic diseases, with particular emphasis on cardiometabolic disorders, hyperglycemia, diabetes, and dyslipidemia. Together, these chapters provide a comprehensive overview of the therapeutic potential of cruciferous vegetables in human health.