Design of Thiazole Derivatives as Anticancer and Antibacterial Agents

This work explores the synthesis and biological evaluation of novel thiazole-based heterocycles in two parts. The first part details the design, synthesis, and anticancer assessment of a new series of amide derivatives containing thiazole-indole-isoxazole scaffolds, identifying several compounds with promising activity against human breast, lung, and prostate cancer cell lines. The second part presents a green, one-pot synthetic strategy for novel thiazolopyridine-conjugated benzamides, which were screened for antibacterial activity against Staphylococcus aureus and Bacillus subtilis. The most active compounds also underwent molecular docking studies, revealing potential inhibition of bacterial DNA gyrase, and their drug-like properties were computationally validated.

Pagina's: 84, Paperback, LAP LAMBERT Academic Publishing