DNA in Supramolecular Chemistry and Nanotechnology

This book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology. DNA-based nanotechnology has advanced tremendously in the past 30 years to become a key player in many different fields of science and research. Nucleotides, no longer merely building blocks of life, can be used like Lego bricks to create new functional entities. These DNA nanostructures play a major role in soft materials, electronics, diagnostics and medicinal chemistry. This book presents a unique collection of accounts of the current research and technology on modified nucleotides and functional DNA systems derived thereof, with contributions from the world’s leading experts. Each article describes the basic research, as well as outlining novel applications and future directions of the field. The contents include: • (Non-)covalently modified DNA with novel functions • DNA wires and electron transport through DNA • Oligonucleotides in sensing and diagnostic applications • Conjugation of DNA with biomolecules and nanoparticles • Alternative DNA structures, switches and nanomachines With new results being published on a daily basis, DNA nanotechnology continues to influence materials, medicinal and biological sciences, driven by demands for applications. Intended for both newcomers and experienced researchers in DNA nanotechnology, this book is an indispensable resource in the lab as well as in the teaching class. This book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology. Many novel structures have been realized in the past decade, which are now being used to create molecular machines, drug delivery systems, diagnosis platforms or potential electronic devices. The book combines many aspects of DNA nanotechnology, including formation of functional structures based on covalent and non-covalent systems, DNA origami, DNA based switches, DNA machines, and alternative structures and templates. This broad coverage is very appealing since it combines both the synthesis of modified DNA as well as designer concepts to successfully plan and make DNA nanostructures. Contributing authors have provided first a general introduction for the non-specialist reader, followed by a more in-depth analysis and presentation of their topic. In this way the book is attractive and useful for both the non-specialist who would like to have an overview of the topic, as well as the specialist reader who requires more information and inspiration to foster their own research.