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Drug-DNA Interactions: Structures and Spectra describes the types of structural and bonding information that can be obtained by using specific physico-chemical methods. Structural and spectroscopic studies of drug-DNA adducts are classified first by bonding types and then by structure type of the drug. ACCESSIBLE, COMPREHENSIVE INFORMATION ON DRUG-DNA INTERACTIONS. This informative guide is a thorough source of information on the structural basis of drug-DNA interactions and their underlying empirical evidence. It helps readers understand the underlying mechanisms of the interactions, thus expediting research and aiding in the more efficient design of new and more effective drugs with lesser side effects. With a wealth of information gleaned from diverse studies and combined in a logical, practical format, Drug-DNA Interactions: Structures and Spectra: Describes what types of structural information can be obtained using particular techniques Classified structural and spectroscopic studies of drug-DNA adducts first by bonding types and then by the structure type of the drug Covers intercalating drugs, groove-binding drugs, covalent-bonding drugs, strand-breaking drugs, and metal-containing drugs Focuses on structural and bonding information obtained by using physico-chemical methods (such as X-ray crystallography, NMR spectroscopy, and molecular modeling), and optical spectroscopy (such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), and infrared (IR) and Raman spectroscopy) This is a hands-on reference for professionals in pharmaceutical industries and academia, pharmacologists, organic chemists, biochemists, and bioanalytical chemists. It also helps students in chemistry, biochemistry, and pharmacology understand the complex drug-DNA interactions that could pave the way for tomorrow's breakthrough therapies. Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.
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