Phytochemicals are increasingly receiving attention for their health-promoting properties in many chronic diseases, including metabolic disorders and their associated complications (diabetes, obesity, metabolic syndrome, non-alcoholic fatty liver disease, and cardiovascular diseases). These health benefits have been related to different biological activities, such as their well-known antioxidant properties, but also their anti-diabetic, anti-obesity, and anti-inflammatory actions, among others. In this regard, it is becoming apparent that phytochemicals can modulate different signalling pathways, which are responsible for these final actions and, therefore, their benefits on health. Phytochemicals are commonly found in the diet and are abundant in fruits, vegetables, olive oil, legumes, cocoa, and beverages such as tea, coffee, and wine. Indeed, because of this wide distribution and their potential effects on health, its consumption could represent a promising protective and therapeutic approach to prevent metabolic diseases and improve health, therefore constituting a significant research field.This Special Issue entitled "Effects of Phytochemicals on Metabolic Diseases and Human Health" aims to highlight the most recent advances in phytochemicals, phytochemical-rich foods, their extracts, and health-promoting benefits in the context of metabolic diseases.
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