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Periodontics has witnessed remarkable advances through innovations in biotechnology, regenerative medicine, and minimally invasive therapy. Traditional periodontal treatment relies mainly on mechanical debridement, surgery, and antimicrobial agents, but these approaches have limitations, including incomplete bacterial elimination, restricted regenerative potential, postoperative discomfort, gingival recession, aesthetic concerns, sensitivity, and unpredictable healing. In response, novel therapeutic strategies are being developed.Advances in tissue engineering, stem cell therapy, biomaterials, and microbiology have introduced promising approaches for periodontal regeneration. Growth factors such as platelet-derived growth factor (PDGF) and bone morphogenetic proteins (BMPs) promote cellular migration, proliferation, and extracellular matrix synthesis, supporting regeneration of alveolar bone, periodontal ligament, and cementum. Mesenchymal stem cells (MSCs) and extracellular vesicles (EVs) are also being investigated for regenerative applications.Laser-assisted therapy using Er and Nd lasers may enhance bacterial reduction and wound healing.
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