Encyclopedia of Psychedelic Pharmacology: An Illustrated Reference to Pharmacokinetics, Pharmacodynamics, Mechanisms, Metabolism, Interactions, Safety, and Clinical Research

A comprehensive illustrated reference to the science of psychedelic drugs, their effects on the brain and body, and their growing role in clinical research.Encyclopedia of Psychedelic Pharmacology brings together the major areas of psychedelic pharmacology, psychopharmacology, neuroscience, clinical pharmacology, pharmacokinetics, pharmacodynamics, drug metabolism, safety, and clinical research in one professional reference.The book examines psilocybin, psilocin, LSD, DMT, 5-MeO-DMT, mescaline, ayahuasca alkaloids, MDMA, ketamine, esketamine, ibogaine, noribogaine, and salvinorin A, along with emerging psychedelic analogues and next-generation therapeutics.Readers will learn how these compounds interact with 5-HT2A and other serotonin receptors, monoamine transporters, NMDA receptors, kappa-opioid receptors, metabolic enzymes, and major brain networks. The book also explains absorption, distribution, metabolism, elimination, receptor binding, neuroplasticity, pharmacogenomics, PK/PD relationships, and individual variability.Detailed sections cover psychedelic drug interactions, serotonin toxicity, cardiovascular effects, psychiatric medication interactions, MAO inhibition, adverse effects, clinical screening, ECG monitoring, laboratory testing, and research safety.The encyclopedia also explores modern psychedelic medicine and clinical trials, including research involving depression, PTSD, anxiety, cancer-related distress, alcohol use, tobacco use, and other substance-use disorders.Fully illustrated with biomedical, molecular, brain, receptor, laboratory, and clinical visuals, the book includes compound monographs, comparative tables, receptor references, metabolism pathways, laboratory methods, neuroimaging, PET, fMRI, EEG, MEG, biomarkers, and PK/PD modeling.Designed for students, researchers, pharmacists, clinicians, psychiatrists, psychologists, neuroscience readers, clinical-research professionals, and serious readers of psychedelic science, this volume provides a clear and organized reference to the compounds, mechanisms, risks, and research shaping modern psychedelic pharmacology.