Evaluation of the analgesic activity: SAC-Pa extract in mice

This study aims to evaluate the analgesic activity of the SAC-Pa extract using algogenic stimuli (0.6% acetic acid administered intraperitoneally, 1% formaldehyde administered intraplantarly, a 56°C heating plate, and tail pinch) to induce pain in mice. Oral administration of the SAC-Pa extract at doses of 250 and 500 mg/kg demonstrates peripheral analgesic activity, as evidenced by the acetic acid test and the formaldehyde test. The extract reduced the number of abdominal writhing episodes induced by acetic acid by 30.35% and 77.25%. It also reduced the time spent licking and biting the paw treated with formaldehyde during the second phase by 71.22% and 82.99%. Oral administration of the SAC-Pa extract (250 and 500 mg/kg) did not demonstrate central analgesic activity. The SAC-Pa extract did not increase the reaction time of mice on the hot plate or when their tails were pinched. These results show that the SAC-Pa extract possesses only peripheral analgesic activity, which could be attributed to the alkaloids it contains.

Pagina's: 52, Paperback, Our Knowledge Publishing