From Genotype to Phenotype

The study of how the effects of different mutations - the genotype of the individual - are modified by other genetic factors and by the environment to produce variable clinical symptoms - the phenotype - is one of the fastest growing areas of human molecular genetics. From Genotype to Phenotype provides a unique review of the mechanisms of interaction between genotype and phenotype, for both common and rare genetic disorders.This book will provide readers with a detailed understanding of common human phenotypes, which will improve disease diagnosis and help determine specific therapeutic measures for the future.Books in the Human Molecular Genetics series are important review volumes covering recent advances in the field for all human molecular geneticists, genetic counsellors and clinicians.

This volume of the Human Molecular Genetics series covers such genotype-phenotype correlations as clinical and environmental aspects, gene structure, expression, and mutation. Also discussed are models of certain diseases and future prospects for treatment and prevention. This book provides the reader with a basic overview of the physical expression of genetic disease before discussing in detail the most recent research and therapeutic developments.