Immune response profiles in children with asthma: Immunopathogenesis of Asthma

Asthma is a public health problem due to its socio-economic impact worldwide. It is considered a chronic inflammatory disease of the airways, causing hyperresponsiveness, obstruction, increased mucus production, and airway remodelling. As studies advance, there is a change in the understanding of the pathophysiology of asthma and the cells and mediators involved in inflammation and remodelling resulting from exacerbations. The recognition that asthma is much more than an inflammatory disorder involving the Th1-Th2 dichotomy led us to conduct this study to determine the crisis versus inter-crisis profile in asthmatic patients. This study shows the profile of cytokines (IL-1ß, IL-4, IL-5, IL-9, IL-10, IL-13, IL-15, IL-17, and IFN-¿), basophils and eosinophils, as well as IgE and IgG4 in 30 asthmatic children during crisis and inter-crisis periods. The correlation between Th1 and Th2, Th17 and Treg cytokine profiles was analysed, and no significant correlations were observed. We observed elevated levels of IL-15 and IFN-¿ in asthmatic patients compared to controls and no significant differences in IL-17 when comparing asthmatic children and controls.

Pagina's: 68, Paperback, Our Knowledge Publishing