IMMUNOLOGY OF ATRIAL FIBRILLATION: ASSESSING THE EFFICACY CATHETER ABLATION

Atrial fibrillation (AF) is a leading cause of cardiovascular morbidity. While catheter ablation is a cornerstone of rhythm control, post-procedural recurrence remains a major clinical challenge. This monograph bridges a critical gap by integrating interventional arrhythmology with clinical immunology to explore the inflammatory mechanisms driving AF.Based on a prospective study at the Syzganov National Scientific Center of Surgery, the authors examine the role of systemic inflammation and key interleukins (IL-1, IL-6, IL-12/IL-23, IL-17A, IL-28A) in atrial remodeling. By tracking the immunological profile of patients before ablation, immediately post-procedure, and at six months, the work reveals distinct inflammatory trajectories associated with sinus rhythm maintenance versus AF recurrence.The research culminates in a novel algorithm for immunological assessment, long-term monitoring, and integrated risk stratification. This empowers clinicians to identify high-risk patients early, personalizing post-procedural care. Intended for cardiologists and researchers, this monograph offers a pioneering perspective on improving interventional AF treatments.