It is recognized that there are three major ways to manage excess body weight-physical activity, diet and bariatric surgery. This is of particular relevance since overweight significantly increases the risk of various diseases and metabolic disorders. The choice of one or a combination of these three approaches is greatly dependent on the patient's individual profile. Numerous fundamental and clinical studies still continue to emphasize their benefits on metabolic parameters, body composition, and quality of life, sometimes with contradictions or controversies.In this Special Issue, we propose a translational point of view on this exciting research area, by establishing cross-communication between fundamental and clinical aspects covering the topic.
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