Lc ms in Drug Bioanalysis

This book covers the various methods of validation for high performance liquid chromatography - mass spectrometry (LC-MS) analytical techniques and their applications in the analysis of a broad range of drugs in modern clinical pharmacology. High performance liquid chromatography – mass spectrometry (LC-MS) combines the separation power of liquid chromatography with the high sensitivity and selectivity of mass spectrometry. Therefore, LC-MS becomes the method of choice for drug bioanalysis in therapeutic drug monitoring, toxicology, and drug discovery and development. LC-MS in Drug Bioanalysis offers discussions on: ● LC-MS/MS method development and validation in a regulated environment ● Internal standard use in LC-MS/MS bioanalysis ● Pitfalls of LC-MS/MS and how to overcome them ● Dried blood spot sampling ● Microflow LC-MS/MS ● LC-MS/MS in therapeutic drug monitoring ● Applications of LC-MS/MS in drug bioanalysis This book will aid readers to improve their skills in LC-MS/MS method development, validation, and applications in the analysis of drugs and their metabolites in complex biological matrices. In addition, this book provides detailed information on the bioanalysis of antidepressants, antipsychotics, steroid hormones, anticancer agents, and drugs of abuse. Newer methodologies are discussed including the use of unique sample preparation techniques and the implementation of imaging mass spectrometry in the localization of drug and drug metabolites in tissues.