Mitochondria and Cell Death

Bol

This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material. Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology,as well as those interested in the study of mitochondria and cell biology.

Bol Partner

This volume reviews the involvement of mitochondria in cell death and disease, covering most aspects of the subject from the molecular to the in vivo level. The role of mitochondria in neurodegenerative, inflammatory and ischaemic diseases, as well as necrosis, apoptosis and ageing is reviewed.