Mitochondrial DNA Mutations in Aging, Disease and Cancer

Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.

This volume presents a comprehensive and current analysis of the role of mitrochondria in aging and diseases. Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle and pancreas in humans are caused by mutations in mitochondrial DNA. Mitochondrial DNA mutations have now been associated with aging and age-related degenerative diseases such as Parkinson's, Huntigton's and Alzheimer's diseases. Changes in structure, function and a number of mitochondria play an important role in carcinogenesis, and the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized.