Molecular and Cell Biology of Human Gene Therapeutics

advanced metastatic disease of solid tumors, dictates that each tumor mass, indeed each individual metastasis, will have a unique antigen and cytokine environment and hence unique response to immune modu­ lation. Most chemotherapeutic regimes require a complete response or a good partial response for cure or good palliation. Written to inform not only basic research scientists and students, but also practising physicians, this volume reviews the evolution of gene transfer as a therapeutic strategy. The latest developments in viral and non-viral vectors for gene therapy are explained. The book then moves on to describe gene therapy applications in a comprehensive range of disease situations including cancer, AIDS, arthritis, cardiovascular and neuromuscular disorders, muscular dystrophy, cystic fibrosis and genetic vaccination. This book should be of interest to clinicians, clinical researchers and basic scientists interested in the development of genetic therapies.