Molecular Biology in Medicinal Chemistry, Volume 21

Explains the identification of molecular targets via cellular assays, reporter genes or transgenic models. This title also presents a survey of the advances in the synthesis, separation and analysis of drugs. It also contains a special section devoted to molecular genetics methods. Molecular Biology and Genetic Engineering have made a great impact on the methods and strategies of modern pharmaceutical and medicinal chemistry, transforming virtually every step in the drug development process, from target finding to drug design and ADMET analysis. Even the synthesis and manufacture of pharmaceutically active compounds has benefited from novel approaches based on molecular biology tools. From the Contents: * Cellular Assays in Drug Discovery * Transgenic Models * Reporter Gene Assay Systems * Stereoselective Synthesis with Recombinant Enzymes * Nucleic Acid Drugs * Enantioseparation of Chiral Drugs * NMR-based Drug Discovery * Pharmacogenomics and Toxicogenomics With its broad coverage and up-to-date treatment, this volume is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular biology tools to study drugs and their action.