Nanoemulsion for Parkinson's Therapy

This book presents the formulation, characterization, and in-vitro evaluation of a ropinirole hydrochloride-loaded nanoemulsion developed to enhance drug solubility, stability, and therapeutic performance for Parkinson's disease management. It describes the systematic optimization of oil, surfactant, and co-surfactant compositions using pseudo-ternary phase diagrams and the water titration method to obtain a stable oil-in-water nanoemulsion. The book discusses the physicochemical characterization of the optimized formulation, including globule size, polydispersity index, viscosity, refractive index, entrapment efficiency, and drug release behavior. It also highlights the improved in-vitro permeation and sustained drug release following the Higuchi kinetic model. This work provides valuable insights into nanoemulsion-based drug delivery systems and serves as a useful reference for researchers, pharmaceutical scientists, and students working in nanotechnology and advanced drug delivery for neurological disorders.