Overcoming Therapeutic Resistance in HER2Positive Brain Metastases: Microenvironment Mediated Mechanisms and Combination Strategies

Overcoming Therapeutic Resistance in HER2-Positive Brain Metastases: Microenvironment-Mediated Mechanisms and Combination Strategies explores the biological and clinical challenges of treating brain metastases in HER2-positive breast cancer. The book focuses on how the unique brain tumor microenvironment contributes to therapeutic resistance by influencing drug delivery, signaling pathways, immune responses, and cellular interactions. It reviews current HER2-targeted therapies, their limitations in the central nervous system, and the molecular mechanisms underlying resistance. Emphasis is placed on emerging combination strategies that integrate targeted agents, immunotherapies, and microenvironment-modulating approaches to improve treatment efficacy. By bridging basic science and clinical insights, this book provides researchers and clinicians with a comprehensive framework for developing more effective, durable therapies for HER2-positive brain metastases.

Pagina's: 144, Paperback, Scholars' Press