PULSATILE DRUG DELIVERY SYSTEMS IN CHRONOTHERAPY: Formulation and Evaluation of Compression-Coated Tablets for Chronotherapeutic Management Nocturnal Asthma

Chronopharmaceutical drug delivery represents a progressive shift in pharmaceutical research, emphasizing the synchronization of drug release with the body's biological rhythms to maximize therapeutic efficacy and minimize adverse effects. This book provides a comprehensive and systematic account of pulsatile drug delivery systems as an advanced oral drug delivery approach designed to meet the time-dependent needs of circadian rhythm-related diseases.The text elaborates on the fundamental principles of chronotherapy and pulsatile drug delivery, detailing their classification, design strategies, mechanisms of drug release, and technological advancements. Special emphasis is placed on time-controlled, site-specific, and stimuli-responsive pulsatile systems, with in-depth discussion of tablet-based, capsule-based, and multiparticulate delivery platforms. The role of polymer science and formulation variables in controlling lag time and release kinetics is thoroughly examined.