Redox Homeostasis and Oxidative Stress in Human Metabolism Disease: 2nd Edition

This Reprint presents a curated collection of original research articles and review papers exploring the role of redox homeostasis and oxidative stress in human metabolism and disease. Redox balance is increasingly recognized as a dynamic regulatory system that integrates metabolic signaling, mitochondrial function, and cellular adaptation to physiological and pathological conditions. Disruption of this balance contributes to the development and progression of a wide spectrum of metabolic, cardiovascular, neurodegenerative, inflammatory, and neoplastic disorders. The articles assembled in this Reprint address key molecular mechanisms underlying redox-regulated processes, including reactive oxygen species signaling, mitochondrial dysfunction, lipid peroxidation, and redox-dependent cell death pathways. Particular emphasis is placed on the translational relevance of redox biology, highlighting its impact on tissue function, disease biomarkers, and therapeutic responsiveness across diverse clinical contexts. By integrating mechanistic insights with experimental and clinical evidence, this Reprint offers a multidisciplinary perspective on contemporary advances in redox research. It is intended for researchers, clinicians, and professionals in molecular medicine, biochemistry, and life sciences who seek to better understand redox-driven pathophysiology and its potential for targeted therapeutic intervention.