Smart Ocular Drug Delivery: Thermosensitive In Situ Gel of Acetazolamide for Glaucoma

This book offers an in-depth exploration of the formulation and evaluation of a temperature-sensitive in-situ ocular gel drug delivery system using Acetazolamide, designed for the effective treatment of glaucoma. Traditional eye drop formulations often suffer from poor bioavailability and rapid drug elimination. In contrast, this innovative thermoresponsive gel transforms from liquid to gel upon instillation in the eye, ensuring prolonged contact time, sustained drug release, and enhanced therapeutic efficacy.Through systematic formulation development, physicochemical characterization, and in-vitro testing, this study demonstrates how smart drug delivery systems can significantly improve ocular drug retention and patient compliance. The work also discusses the potential of such advanced formulations to overcome the challenges associated with conventional glaucoma therapies.Ideal for pharmaceutical scientists, researchers, and students, this book bridges theoretical knowledge with practical application, making it a valuable reference in the field of novel drug delivery systems and ocular pharmacology.