Synthesis AND Anticancer Evaluation OF NOVEL 1,3-THIAZOLIDIN-4-ONES: From to

Name: Synthesis AND Anticancer Evaluation OF NOVEL 1,3-THIAZOLIDIN-4-ONES: From to
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Bol A series of novel 2-(substitutedphenyl)-5-methyl-3-(pyridin-4-yl)-1,3-thiazolidin-4-ones (4a-g) were synthesized and structurally confirmed by elemental analysis, IR, 1H NMR and MS spectral data. All the synthesized 1,3-thiazolidin-4-one analogues (4a-g) at various concentrations (10, 20, 50, 100 and 200 mcg/ml) have been evaluated for in vitro cytotoxicity against Dalton's lymphoma ascites (DLA) cancer cell line by trypan blue exclusion method, in comparison with standard drug doxorubicin hydrochloride. Out of these seven compounds, two compounds 2-(2,4-dichlorophenyl)-5-methyl-3-(pyridin-4-yl)-1,3-thiazolidin-4-one (4b) and 2-(4-bromophenyl)-5-methyl-3-(pyridin-4-yl)-1,3-thiazolidin-4-one (4g) inhibited 100% and 78% DLA tumor cells at 100 mcg/ml concentration, whereas standard drug doxorubicin exhibit 100% DLA inhibition at a concentration of 100 mcg/ml.

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A series of novel 2-(substitutedphenyl)-5-methyl-3-(pyridin-4-yl)-1,3-thiazolidin-4-ones (4a-g) were synthesized and structurally confirmed by elemental analysis, IR, 1H NMR and MS spectral data. All the synthesized 1,3-thiazolidin-4-one analogues (4a-g) at various concentrations (10, 20, 50, 100 and 200 mcg/ml) have been evaluated for in vitro cytotoxicity against Dalton's lymphoma ascites (DLA) cancer cell line by trypan blue exclusion method, in comparison with standard drug doxorubicin hydrochloride. Out of these seven compounds, two compounds 2-(2,4-dichlorophenyl)-5-methyl-3-(pyridin-4-yl)-1,3-thiazolidin-4-one (4b) and 2-(4-bromophenyl)-5-methyl-3-(pyridin-4-yl)-1,3-thiazolidin-4-one (4g) inhibited 100% and 78% DLA tumor cells at 100 mcg/ml concentration, whereas standard drug doxorubicin exhibit 100% DLA inhibition at a concentration of 100 mcg/ml.

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