The Clinics: Internal MedicineVolume 39 5 Chronic Lymphocytic Leukemia, An Issue of Hematology/Oncology Clinics North America

In this issue of Hematology/Oncology Clinics, guest editors Drs. Jennifer R. Brown and Matthew S. Davids bring their considerable expertise to the topic of Chronic Lymphocytic Leukemia. Top experts provide in-depth perspectives on CLL, including basic biology, frontline and relapsed refractory treatments, mechanisms of resistance to targeted therapies, Richter’s transformation, and some of the common complications of the disease stemming from immune dysfunction-offering a state-of-the-art overview of the field to help optimize the care of patients with CLL. Contains 13 relevant, practice-oriented topics including autonomous B cell receptor signaling; triple drug combinations; management of relapsed/refractory CLL; resistance to BTK inhibitors; immune therapy for CLL; and more Provides in-depth clinical reviews on chronic lymphocytic leukemia, offering actionable insights for clinical practice Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews