The Placenta and Neurodisability

Bol

This comprehensive and authoritative book discusses the critical role of the utero-placenta in neurodisability, both at term and preterm. It examines aspects of fetal compromise and possible cerebro-protective interventions, recent evidence on fetal growth and mental illness, as well as cerebro-therapeutics. This comprehensive and authoritative book discusses the critical role of the utero-placenta in neurodisability, both at term and preterm. It examines aspects of fetal compromise and possible cerebro-protective interventions, recent evidence on fetal growth and mental illness, as well as cerebro-therapeutics. Throughout the book, information from the basic sciences placed within the clinical context. Written by leading obstetricians, neonatologists, paediatricians and pathologists. Discusses the role of placenta in the pathophysiology of CNS Examines recent evidence of endocrine, haematological and inflammatory origins of utero-placental dysfunction Reviews latest advances in antepartum and perinatal imaging

Bol Partner

What are the interactions between altered placental function and neurodisability? In this book a team of experts give detailed accounts of placental lesions that affect normal structure and function to show how impaired placental function may contribute to deviant fetal growth and altered brain development. They outline the processes that lead to brain injury, and show the extent to which such early effects on brain development lead to disability in later childhood. Chapters focus on the specific transporter systems located in the placental syncytiotrophoblast that protect the fetus from drugs and xenobiotics in the maternal circulation. They also look at the animal models used to study causes of fetal brain damage, and the interactions between fetal genes and the uterine environment that predispose to the development of schizophrenia in adult life.