Wohl Ziegler Bromination

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Bol Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The Wohl-Ziegler reaction is a chemical reaction that involves the allylic or benzylic bromination of hydrocarbons using an N-bromoimide and a radical initiator. Best yields are achieved with N-bromosuccinimide in carbon tetrachloride solvent. Several reviews have been published. In a typical setup a stoichiometric amount of N-bromosuccinimide solution and a small quantity of initiator are added to a solution of the substrate in CCl4, and the reaction mixture is stirred and heated to the boiling point. Initiation of the reaction is indicated by more vigorous boiling; sometimes the heat source may need to be removed. Once all N-bromosuccinimide (which is denser than the solvent) has been converted to succinimide (which floats on top) the reaction has finished.

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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The Wohl-Ziegler reaction is a chemical reaction that involves the allylic or benzylic bromination of hydrocarbons using an N-bromoimide and a radical initiator. Best yields are achieved with N-bromosuccinimide in carbon tetrachloride solvent. Several reviews have been published. In a typical setup a stoichiometric amount of N-bromosuccinimide solution and a small quantity of initiator are added to a solution of the substrate in CCl4, and the reaction mixture is stirred and heated to the boiling point. Initiation of the reaction is indicated by more vigorous boiling; sometimes the heat source may need to be removed. Once all N-bromosuccinimide (which is denser than the solvent) has been converted to succinimide (which floats on top) the reaction has finished.


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  • 9783639961614
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